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1 1 3 . Beecham G r o u p L t d . , Neth. A p p l . A. 6 6 , 28763m ( 1 9 6 7 ) . 114. , Belg. A. 5 8 , 7534d ( 1 9 6 3 ) . Brit. 1 1 5 . Novo T e r a p e u t i s k L a b o r a t o r i u m A / s . , 9 8 5 , 6 5 5 , March 10, 1 9 6 5 ; C . A . 6 2 , 1 5 3 (1965). 116. Doyle, F . P . , F o s k e r , G . R . , N a y l e r , J . H . Chem. S O C . 1 9 6 2 , 1 4 4 0 . 117. F o s k e r , G . R . , N a y l e r , J . H . C . an d W i l c o x , J . A . , B r i t . 9 9 1 , 5 8 6 , May 1 2 , 1 9 6 5 : C . A .
This may be assayed spectrophotometricallyl69. 2 at 75OC and the absorbance is measured at 320 nm 170. Smith's method €or the spectrophotometric determination of ampicillin was adapted to the assay of ampicillin in chicken blood, bile and urinel7+ Ampicillin is dissolved in 5 g sodium hydroxide and the absorbance is measured at 279 Ampicillin is determined spectrophotometrically as its copper complexl73. Spectrophotometric and circular dichroism methods for determining the activity of ampicillin are described174.
A. 61, 14476g (1964). 145. G. , Brit. A. 70, 14410r ~ EUGENE I V A S H K I V (1969). 146. Dewdney, J . W. and S m i t h , H . , 2. A f r i c a n 6,803,094 O c t o b e r 1968: C . A . 71, 6526p (1969). 147. Beecham Group L t d . , F r . 1,526,417,May 1968: C . A . 71, 33414g (1969). 148. , Nys, P . S . -Farm. Sh. 1969, 3(7), 32-8. 149. J o h n s o n , D . A . a n d H a r d c a s t l e , G . A . S. 3,271,389,S e p t e m b e r 1966: C . A . 66, 10930m (1967). 150. , N e r i , C . a n d S u d a n o , F .