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Additional info for Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.: Proceedings of the 22st Postgraduate Course in Critical Medicine Venice-Mestre, Italy - November 9-11, 2007
7-11 kDa). This has become possible when using microdialysis catheters with large pore membranes and a molecular cut-off of 100,000 Da or higher [12, 13]. Furthermore, microdialysis emerges as a truly unique tool for monitoring the free fraction of drugs in catheters placed in tissues and organs or in the blood using intravenous microdialysis catheters. It becomes possible to evaluate the penetration of drugs over the blood brain barrier both when it is intact and when it is damaged  and the extent to which antibiotics, for example, reach an infected organ.
Jardin F, Dubourg O, Bourdarias JP (1997) Echocardiographic pattern of acute cor pulmonale. Chest 111:209-217 35. Durack DT, Lukes AS, Bright DK et al (1994) New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke endocarditis service. Am J Med 96:200-209 Chapter 3 Use of Pulse Oximeter Waveform as a Non Invasive Functional Haemodynamic Monitoring Technique M. -J. LEHOT Recently published studies have shown that intraoperative fluid optimization decreases postoperative morbidity and hospital stay .
In this chapter, after a brief overview regarding the concept of fluid responsiveness, we will see that: (1) the respiratory variations in the pulse oximeter plethysmographic waveform are related to the respiratory variations in the arterial waveform, (2) this waveform is able to detect changes in ventricular preload, and (3) the respiratory variations in this waveform are accurate predictors of fluid responsiveness in mechanically ventilated patients. 24 M. -J. Lehot Fluid Responsiveness Fluid responsiveness prediction has been extensively studied in the intensive care unit and operating room in mechanically ventilated patients.