ALI and ARDS: Challenges and Advances, An Issue of Critical by Lena M. Napolitano MD, Krishnan Raghavendran MD

By Lena M. Napolitano MD, Krishnan Raghavendran MD

This factor of severe Care Clinics will specialise in serious Acute respiration misery Syndrome and working with it within the ICU. subject matters will contain: demanding situations and Successes in ARDS Research;Mechanical air flow with Lung protecting options: What works?; Gene treatment for ALI/ARDS;High Frequency Oscillatory air flow in ALI/ARDS;Prone positioning treatment in ARDS;Recovery and long term consequence in ARDS; and Experimental versions and emergeing hypotheses for ALI and ARDS

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Additional info for ALI and ARDS: Challenges and Advances, An Issue of Critical Care Clinics (The Clinics: Internal Medicine)

Example text

There is considerable variation in current recommendations about how to best use and adjust intravenous fluids, and there were no large randomized clinical trials available to guide clinicians. This trial tested a fluid liberal strategy (that would be expected to improve the overall state of the circulation) against a fluid conservative strategy (that would potentially avoid excess lung fluid accumulation). A second goal of this trial was to determine whether a pulmonary artery catheter (PAC) is superior to a smaller, and less invasive central venous catheter (CVC) in the management of patients with ARDS.

Am J Respir Crit Care Med 2007;176(3):270–6. 59. Berkowitz DM, Danai PA, Eaton S, et al. Alcohol abuse enhances pulmonary edema in acute respiratory distress syndrome. Alcohol Clin Exp Res 2009; 33(10):1690–6. 60. Iribarren C, Jacobs DR Jr, Sidney S, et al. Cigarette smoking, alcohol consumption, and risk of ARDS: a 15-year cohort study in a managed care setting. Chest 2000;117(1):163–8. 61. Calfee CS, Matthay MA, Eisner MD, et al. Active and passive cigarette smoking and acute lung injury following severe blunt trauma.

4 ALVEOLI STUDY Study status: Completed. Study dates: November 1999 to March 2002. Prospective, Randomized, Multi-Center Trial of Higher End-Expiratory Lung Volume/Lower FiO2 versus Lower End-expiratory Lung Volume/Higher FiO2 Ventilation in Acute Lung Injury and Acute Respiratory Distress Syndrome. This study was a prospective, randomized, controlled multicenter trial. The objective was to compare clinical outcomes of patients with ALI and ARDS treated with a higher end-expiratory lung volume/lower FiO2 versus a lower end-expiratory lung volume/higher FiO2 ventilation strategy.

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